Mechanism of Action
RADIESSE® is an injectable implant composed of smooth calcium hydroxylapatite (CaHA) microspheres (diameter of 25 Âµm to 45 Âµm) suspended in a sodium carboxymethylcellulose gel carrier. RADIESSE is approximately 30% CaHA and 70% gel carrier by volume.
RADIESSE is injected under the skin in a minimally invasive procedure. Injection of the product provides an immediate and visible correction to the wrinkle. There is no skin sensitivity testing or reconstitution required.
Over time, the gel is absorbed, and fibroblasts appear. The process of neocollagenesis begins, stimulating the gradual growth of the patient’s own collagen.1 The collagen that forms results in extended correction and increased patient satisfaction. RADIESSE® builds structural scaffolding by stimulating collagen production for a year or longer after only 1 injection.
Histology slides demonstrate deposition of new collagen around CaHA microspheres over an extended period of time. Collagen fibers stain red, while other tissue elements appear more yellow.
The cosmetic results are immediate, natural and subtle. The correction is long-lasting, but not permanent. The CaHA microspheres naturally degrade to calcium and phosphate ions, which are metabolized by the body’s normal processes.
It is important to remember not to overcorrect (overfill) a contour deficiency with RADIESSE because the depression should gradually improve within several weeks as the treatment effect of RADIESSE occurs.
Common adverse events seen in clinical studies of RADIESSE® injected into the dorsum of the hand include bruising, redness, swelling, pain, itching, nodule or bumps/ lumps, difficulty performing activities, loss of sensation, and other local side effects. Common adverse events seen in clinical studies of RADIESSE® or RADIESSE® (+) injected into the face include bruising, redness, swelling, pain, itching, and other local side effects.
RADIESSE® for Lower Face
RADIESSE provides an instant lift and definition for natural-looking results that can last a year or longer in many patients.
RADIESSE® for Hands
RADIESSE is the only dermal filler proven to immediately restore volume loss in the back of the hands for smooth, natural-looking results.
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